Erika Shinohara (Fumi Nikaido) is a first year of high school student. While talking to friends, she makes up a story about her "boyfriend." In reality, Erika Shinohara doesn't have a boyfriend. Erika's friends soon begin to doubt her story and Erika is also running out of lies. Erika then sees a pretty boy on the street and takes his picture discreetly. She later shows his picture to her friends as her boyfriend. The boy in the picture is Kyouya Sata (Kento Yamazaki) and happens to attend the same school as Erika. She tells Kyouya about her situation and asks him to be her pretend boyfriend. Even though Kyouya has a pretty appearance, he has a dark side.
A mysterious creature destroys 70% of the moon. The creature then warns that if he is not destroyed by March of next year, Earth will be next. The creature also demands that he becomes the homeroom teacher for 3rd grade E class at Kunugigaoka Junior High School. The government is powerless to say no.
The creature then becomes the homeroom teacher of 3rd grade E class which consists of failed students including Nagisa Shiota (Ryosuke Yamada). The creature is called Teacher Koro.
Meanwhile, the government requests that the students try to kill Teacher Koro even though he possesses super powers. The government offers a 10 billion yen reward for whomever successfully kills him. The students are confused by the situation, but decide to kill Teacher Koro.
When their class begins with Teacher Koro, the students finds themselves having a good time with their new teacher.
High school student Jinta (Nijiro Murakami) is a hikikomori and lives in Chichibu, Saitama Prefecture, Japan. One summer day, when Jinta is absorbed in a video game, a girl suddenly appears in front of him. The girl is Jinta's childhood friend Meiko (Minami Hamabe), but it seems impossible because Meiko died on a summer day. Meiko wears the same white dress when she died, but she looks a little taller. She tells Jinta that she has a wish and that's why she came back as a ghost, but Meiko can't remember what her wish was.
To grant Meiko's wish, Jinta along with his friends Atsumu (Jun Shison), Naruko (Airi Matsui), Chiriko (Marie Iitoyo), Tetsudo (Yuta Takahata) and Meiko gather together for the first time in 7 years. Jinta soon realizes that he is the only one able to see Meiko.
Ayumi Nitta (Erika Toda) suffers from anthropophobia (extreme shyness & fear of people). She works as a janitor at a hospital. One evening, she has an one night stand with surgeon Wataru Makino (Tori Matsuzaka) who is addicted to sex. Ayumi later realizes she is now pregnant because of that one night stand. When she tells Wataru that she is pregnant, Wataru believes she is a making a bad April Fools joke. Wataru Makino then takes flight attendant Reiko (Nanao) out to an Italian restaurant. He doesn't know that Ayumi Nitta is also going to the same restaurant.
Rieko Nishiwaki (Miki Mizuno) is released from prison after spending 8 years incarcerated on a false charge. She seeks out her former best friend who betrayed her and she comes across a young murderess.
Detective Keita Kurokouchi (Tomoya Nagase) continues to extort money from politicians whom Keita Kurokouchi has information on. By using his information he is able to crack unsolved cases. Rookie Detective Mayo Seike (Ayame Gouriki) is excellent with her job and also a bit naive. She conducts an internal investigation on Detective Keita Kurokouchi, but they become partners and work on cases together.
Junko Sakuraba (Satomi Ishihara) dreams of working in New York, but she currently works as an English conversation teacher. She's about to have her 29th birthday. Junko Sakuraba works hard to achieve her dream, but New York seem far away. She has also not dated in a long time.
Junko Sakuraba attends a funeral held at a temple. During the funeral, she makes a mistake and throws ashes onto a monk chanting a sutra. She feels apologetic and embarrassment.
Later, Junko Sakuraba's family deceives her into going on a blind date. The man she meets on the blind date is Takane Hoshikawa (Tomohisa Yamashita). Her date is the monk whom she accidentally threw ashes on.
Kazuko Yamase (Aoi Morikawa) is a 23-year-old, broken-hearted freeter. One day, she sees a knitted teddy bear that really appeals to her. She decides to buy it. Later, the knitted teddy bear suddenly speaks! Within the teddy bear, Yasuo Amano's (Sho Aikawa) spirit lives. He is the person who knitted the teddy bear and he was also detective. Kazuko then becomes involved in a case with Yasuo and helps to solve the case.